Aim:

The lncRNA growth arrest-special 5 (GAS5) is a critical tumor suppressor lncRNA, and its expression level has been found to be decreased in many types of cancers. So GAS5 polymorphisms are also likely to influence predisposition to many types of malignant diseases. Nevertheless, the relationships between GAS5 polymorphisms and cancer are still controversial. Thus, the authors designed this meta-analysis to get a more statistically reliable conclusion.

Methods:

The authors searched PubMed, Embase, and Web of Science for eligible studies. A total of 12 eligible studies involving 8693 cancer cases and 10,805 controls were pooled and analyzed in this meta-analysis.

Results:

Among GAS5 polymorphisms, only GAS5 rs145204276 insertion/deletion polymorphism could be analyzed in a meta-analysis with regard to predisposition to cancer since no any other GAS5 polymorphisms were explored by at least two individual genetic association studies. All eligible studies were found to be of Asian origin. Although the overall pooled meta-analysis results did not show any significant associations between rs145204276 insertion/deletion polymorphism and a predisposition to cancer, rs145204276 insertion/deletion polymorphism was demonstrated to be significantly associated with a predisposition to gastric cancer (dominant comparison: P<0.0001; recessive comparison: P=0.005; over-dominant comparison: P=0.0003; over-dominant comparison: P<0.0001) in Asians in further subgroup analyses.

Conclusions:

This meta-analysis demonstrated that GAS5 rs145204276 insertion/deletion polymorphism was associated with a predisposition to gastric cancer in Asians. Nevertheless, considering that this positive finding was only based on three eligible studies from the same area, future studies with larger sample sizes in other populations are still warranted to test the robustness of our findings.

中文翻译：

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LncRNA 生长停滞-特殊 5 多态性和癌症易感性：荟萃分析

目标：

lncRNA生长停滞-特殊5（GAS5）是一种关键的肿瘤抑制lncRNA，已发现其在多种癌症中的表达水平降低。因此GAS5多态性也可能影响多种恶性疾病的易感性。尽管如此，GAS5多态性与癌症之间的关系仍存在争议。因此，作者设计了这个荟萃分析以获得更可靠的统计结论。

方法：

作者在 PubMed、Embase 和 Web of Science 中搜索了符合条件的研究。在这项荟萃分析中汇集和分析了总共 12 项符合条件的研究，涉及 8693 例癌症病例和 10,805 例对照。

结果：

在 GAS5 多态性中，只有 GAS5 rs145204276 插入/缺失多态性可以在关于癌症易感性的荟萃分析中进行分析，因为至少两个单独的遗传关联研究没有探索任何其他GAS5多态性。发现所有符合条件的研究均来自亚洲。尽管总体汇总荟萃分析结果未显示 rs145204276 插入/缺失多态性与癌症易感性之间存在任何显着关联，但 rs145204276 插入/缺失多态性被证明与胃癌易感性显着相关（显性比较：P <0.0001 ；隐性比较：P = 0.005；超显性比较：P=0.0003; 在进一步的亚组分析中，超显性比较：P <0.0001）在亚洲人中。

结论：

该荟萃分析表明，GAS5 rs145204276 插入/缺失多态性与亚洲人的胃癌易感性相关。尽管如此，考虑到这一积极发现仅基于来自同一地区的三项合格研究，未来在其他人群中进行更大样本量的研究仍然有必要检验我们研究结果的稳健性。