Background: Sepsis-related mortality is driven by immune dysfunction. A bidirectional micro-organism–immune cell cross talks exists. Gut Bacteroides fragilis–T-cell crosstalk maintains innate immune cell/pathogen homeostasis. Commensal gut Clostridia spp. suppress inflammation and induce gut tolerance. Probiotics are administered to restore immune microbiome homeostasis. Individual microbial components have an immunomodulatory effect. However, probiotic therapies for sepsis-induced immune disruptions are rarely tailored to specific immune responses. Thus, we ask the question as to how components of the intestinal microbiome, often found in probiotic therapies, affect lymphocyte phenotypic profile?

中文翻译：

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揭示微生物组独特的免疫改变方面作为纠正败血症引起的免疫功能障碍的工具

背景：脓毒症相关死亡率是由免疫功能障碍驱动的。存在双向微生物-免疫细胞交叉对话。肠道脆弱拟杆菌- T 细胞串扰维持先天免疫细胞/病原体稳态。共生肠梭菌属。抑制炎症并诱导肠道耐受。给予益生菌以恢复免疫微生物组的稳态。个别微生物成分具有免疫调节作用。然而，针对败血症引起的免疫破坏的益生菌疗法很少针对特定的免疫反应进行定制。因此，我们提出了一个问题，即肠道微生物组的成分（通常在益生菌疗法中发现）如何影响淋巴细胞表型谱？