Abstract

Due to the sophisticated hierarchical structure and limited reparability of articular cartilage (AC), the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine. As defects progress, they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis. Tissue engineering techniques bring new hope for AC regeneration. To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue, a substantial number of multilayered biomimetic scaffolds have been studied. Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue. This review focuses on the current status of multilayered scaffolds developed for AC defect repair, including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue, the selection and composition of biomaterials, and techniques for design and manufacturing. The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed.

中文翻译：

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仿生多层关节软骨再生支架的研究进展与展望

摘要

由于复杂的层次结构和关节软骨（AC）的可修复性有限，AC缺损的理想再生一直是再生医学领域的主要挑战。随着缺陷的发展，它们通常从软骨层延伸到软骨下骨，并最终导致骨关节炎。组织工程技术为交流再生带来了新希望。为了满足天然AC组织的异质和分层结构的再生要求，已经研究了大量的多层仿生支架。理想的多层支架应产生与天然AC组织相似的区域特异性功能组织。这篇评论着重于为AC缺陷修复开发的多层支架的现状，包括基于缺陷严重程度和AC组织特定区域特征的设计策略，生物材料的选择和组成以及设计和制造技术。还讨论了仿生多层支架策略用于AC再生的挑战和未来前景。