UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: development of antibacterial nanofibrous hydrogel,MRS Communications

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UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: development of antibacterial nanofibrous hydrogel
MRS Communications ( IF 1.8 ) Pub Date : 2020-09-30 , DOI: 10.1557/mrc.2020.74
G M Estrada-Villegas ₁ , J I Del Río-De Vicente ₁ , L Argueta-Figueroa ₂ , G González-Pérez ₃

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UV-initiated crosslinking of electrospun poly(ethylene) oxide (PEO)/chitosan (CS) nanofibers doped with zinc oxide nanoparticles (ZnO-NPs) was performed using pentaerythritol triaclyrate (PETA) as the photoinitiator and crosslinker agent. The influence of the addition of PETA to the PEO/CS diameter and crosslinking of nanofibers was evaluated. The effect of irradiation time on the morphology and swelling properties of the crosslinked nanofibers were investigated. For ZnO-NPs, the minimum inhibitory concentrations were found at 1 mg/mL, and the minimum bactericidal concentrations at 2 mg/mL for all the strains tested. The nanofibrous hydrogel antibacterial effect was tested. This material enters the realm of fibrous hydrogels which have potential use in several applications as in the biomedical area. Supplementary material The supplementary material for this article can be found at 10.1557/mrc.2020.74.

中文翻译：

掺杂 ZnO 纳米粒子的电纺壳聚糖/聚环氧乙烷纳米纤维的紫外引发交联：抗菌纳米纤维水凝胶的开发

使用季戊四醇三丙烯酸酯 (PETA) 作为光引发剂和交联剂，对掺杂有氧化锌纳米粒子 (ZnO-NPs) 的电纺聚环氧乙烷 (PEO)/壳聚糖 (CS) 纳米纤维进行紫外引发交联。评估了添加 PETA 对 PEO/CS 直径和纳米纤维交联的影响。研究了辐照时间对交联纳米纤维形态和溶胀性能的影响。对于 ZnO-NPs，所有测试菌株的最低抑菌浓度为 1 mg/mL，最低杀菌浓度为 2 mg/mL。测试了纳米纤维水凝胶的抗菌效果。这种材料进入了纤维水凝胶领域，在生物医学领域等多种应用中具有潜在用途。

更新日期：2020-09-30

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