Acteoside (ACT) belongs to a type of phenylethanoid glycosides (PhGs), and it is worthy of obtaining high-purity due to its significant medicinal functions. In this study, a novel class of MIMs was designed and synthesized with PVDF membranes as the base membrane for high selective separation and enrichment of ACT. The effects of the different functional monomers, the amounts of functional monomers, crosslinking agents, and initiators on the separation properties of MIMs were investigated. Furthermore, adsorption ability, permeation capacity, and reusability of MIMs were discussed for ACT. It indicated that MIM7 was the optimal performance of MIMs. The adsorption ability of MIM7 for ACT was 62.83 mg/g, and the selectivity factor (α) of MIM7 was up to 2.74 and its permeability factor (β) was greater than 2.66. Moreover, the adsorption amount of MIM7 was still more than 88.57% of the initial value after five cycles. As an ACT imprinted layer of MIMs only had recognition sites for ACT molecules, which recombined with the recognition sites in the membrane permeation experiment, ACT molecules penetration was hindered. However, the analogs of ECH successfully passed MIMs. It indicated that the selective MIMs for ACT followed the mechanism of delayed permeation. This work provides an important reference for the high permselective separation of natural products.

Acteoside（ACT）属于一类苯乙醇类糖苷（PhGs），由于其重要的药用功能，值得获得高纯度。在这项研究中，设计并合成了新型的MIM类，以PVDF膜为基膜，可高度选择性地分离和富集ACT。研究了不同功能单体，功能单体的数量，交联剂和引发剂对MIMs分离性能的影响。此外，讨论了ACT的MIM的吸附能力，渗透能力和可重复使用性。这表明MIM7是MIM的最佳性能。MIM7对ACT的吸附能力为62.83 mg / g，MIM7的选择性因子（α）最高为2.74，渗透率（β）大于2.66。此外，5个循环后，MIM7的吸附量仍大于初始值的88.57％。由于MIM的ACT印迹层仅具有ACT分子的识别位点，在膜渗透实验中与ACT分子的识别位点重新结合，因此ACT分子的渗透受到阻碍。但是，ECH的类似物成功通过了MIM。这表明针对ACT的选择性MIM遵循延迟渗透的机制。这项工作为天然产物的高选择性分离提供了重要参考。ECH的类似物成功通过了MIM。这表明针对ACT的选择性MIM遵循延迟渗透的机制。这项工作为天然产物的高选择性分离提供了重要参考。ECH的类似物成功通过了MIM。这表明针对ACT的选择性MIM遵循延迟渗透的机制。这项工作为天然产物的高选择性分离提供了重要参考。