The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is emerging as a common feature to target in most CNS pathologies. Recent studies suggest that targeted delivery of small molecules to reduce neuroinflammation can be beneficial. However, suboptimal drug delivery to the CNS is a major barrier to modulate inflammation because neurotherapeutic compounds are currently being delivered systemically without spatial or temporal control. Emerging nanomaterial technologies are providing promising and superior tools to effectively access neuropathological tissue in a controlled manner. Here we highlight recent advances in nanomaterial technologies for drug delivery to the CNS. We propose that state-of-the-art nanoparticle drug delivery platforms can significantly impact local CNS bioavailability of pharmacological compounds and treat neurological diseases.

对于大多数神经系统疾病缺乏有效的治疗方法促使人们寻求新的治疗选择。有趣的是，神经炎症正在成为大多数中枢神经系统病理学中常见的靶标。最近的研究表明，靶向递送小分子以减少神经炎症可能是有益的。但是，将药物传递至CNS的最佳条件是调节炎症的主要障碍，因为目前神经系统治疗化合物的给药是在没有空间或时间控制的情况下进行的。新兴的纳米材料技术正在提供有前途且优越的工具，以可控的方式有效地进入神经病理组织。在这里，我们重点介绍了用于将药物输送到中枢神经系统的纳米材料技术的最新进展。