How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

中文翻译：

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为转录和CTCF设置新的界限

边界元素如何将染色体划分为多个域？一项新的研究使用随机基因组插入来显示小基因组片段如何通过环挤出和区室化的相互作用来塑造染色质折叠。剧透：上下文很重要。