Abstract

Patients with atopy were found to exhibit blunted cortisol responses to acute stress stimuli. The aim of this study was to test the hypothesis that cumulative cortisol concentrations in the hair of patients with atopy are lower than in healthy subjects when related to their perceived stress experience. The sample consisted of 31 participants. The most proximal 3 cm of hair (as close to the scalp as possible), reflecting the cumulative cortisol secretion during the previous 3 months, was used for the analysis. Only in 20 subjects (9 patients with atopy and 11 healthy controls), there was a sufficient amount of hair for precise analysis using a new methodology. The results showed lower hair cortisol concentrations in patients with atopy compared to those in controls. The perceived stress scores in patients with atopy and healthy controls were not statistically different. The cortisol concentration/perceived stress score ratios were lower in patients with atopy compared to those in controls. No statistically significant correlation between hair cortisol and long-term experienced stress assessed via perceived stress scale was observed. In conclusion, the cumulative cortisol secretion in the hair of atopic patients is lower than would be expected according to their subjective scores of perceived stress. Most importantly, the previously lower stress hormone increase found in acute stress situations and in children now was confirmed in adult patients with chronic stress load.

摘要

发现患有特应性疾病的患者表现出对急性应激刺激的皮质醇反应迟钝。这项研究的目的是检验以下假设：特应性疾病患者的头发中累积的皮质醇浓度与健康受试者的感觉压力相关时低于健康受试者。样本包括31名参与者。分析使用了最近的3 cm头发（尽可能靠近头皮），以反映前三个月累积的皮质醇分泌。仅在20名受试者（9名特应性疾病患者和11名健康对照）中，有足够数量的头发用于使用新方法进行精确分析。结果显示，特应性患者的头发皮质醇浓度低于对照组。具有特应性和健康对照的患者的感知压力得分在统计学上没有差异。与对照组相比，特应性疾病患者的皮质醇浓度/感知压力评分比率更低。没有观察到头发皮质醇和通过感知的压力量表评估的长期经历的压力之间的统计学显着相关性。总之，特应性患者的头发中累积的皮质醇分泌低于根据他们对压力的主观评分所预期的水平。最重要的是，在患有慢性压力负荷的成年患者中证实了以前在急性压力情况下和儿童中发现的较低的压力激素增加。与对照组相比，特应性疾病患者的皮质醇浓度/感知压力评分比率更低。没有观察到头发皮质醇和通过感知的压力量表评估的长期经历的压力之间的统计学显着相关性。总之，特应性患者的头发中累积的皮质醇分泌低于根据他们对压力的主观评分所预期的水平。最重要的是，在患有慢性压力负荷的成年患者中证实了以前在急性压力情况下和儿童中发现的较低的压力激素增加。与对照组相比，特应性疾病患者的皮质醇浓度/感知压力评分比率更低。没有观察到头发皮质醇和通过感知的压力量表评估的长期经历的压力之间的统计学显着相关性。总之，特应性患者的头发中累积的皮质醇分泌低于根据他们对压力的主观评分所预期的水平。最重要的是，在患有慢性压力负荷的成年患者中证实了以前在急性压力情况下和儿童中发现的较低的压力激素增加。异位患者的头发中累积的皮质醇分泌低于根据他们的主观感知压力得分所预期的水平。最重要的是，在患有慢性压力负荷的成年患者中证实了以前在急性压力情况下和儿童中发现的较低的压力激素增加。异位患者的头发中累积的皮质醇分泌低于根据他们的主观感知压力得分所预期的水平。最重要的是，在患有慢性压力负荷的成年患者中证实了以前在急性压力情况下和儿童中发现的较低的压力激素增加。