Abstract

Vaccines are the most important life-saving prophylactic medicines administered in maintaining global health. In a pandemic situation, the manufacturing, formulation followed by preservation of vaccine are challenging areas of concern looking at the dire need of administering it to several billion people on the planet in a pandemic like situation. An important area of major concern is the potential loss of vaccine activity during storage and transportation. Scientists have developed several innovative ideas to store vaccines for a longer period of time. This article focuses on a critical overview of various methods of vaccine storage in dry powder form. Conventional vaccine drying processes, such as freeze drying under different conditions, spray drying along with the upcoming novel technologies such as spray freeze drying are described in detail for the application in vaccine drying. Some other emerging methods, such as, microwave freeze drying and atmospheric freeze drying techniques are also discussed; these could be the game changers in the future. Several drying techniques make use of protective agents during the process of drying and storage. This review also highlights a comparative study of various technological challenges in drying of vaccines in support of the current global health scenario affected by COVID19.

摘要

疫苗是维持全球健康的最重要的挽救生命的预防性药物。在大流行的情况下，疫苗的制造、配制和保存是具有挑战性的关注领域，因为迫切需要在类似大流行的情况下将疫苗施用于地球上的数十亿人。主要关注的一个重要领域是在储存和运输过程中疫苗活性的潜在损失。科学家们已经开发出几种创新的想法来更长时间地储存疫苗。本文重点概述了以干粉形式储存疫苗的各种方法。常规的疫苗干燥工艺，如不同条件下的冷冻干燥，喷雾干燥以及即将出现的新技术，如喷雾冷冻干燥，详细描述了在疫苗干燥中的应用。还讨论了其他一些新兴方法，例如微波冷冻干燥和常压冷冻干燥技术；这些可能是未来的游戏规则改变者。几种干燥技术在干燥和储存过程中使用保护剂。这篇综述还强调了对疫苗干燥中各种技术挑战的比较研究，以支持当前受 COVID19 影响的全球健康状况。几种干燥技术在干燥和储存过程中使用保护剂。这篇综述还强调了对疫苗干燥中各种技术挑战的比较研究，以支持当前受 COVID19 影响的全球健康状况。几种干燥技术在干燥和储存过程中使用保护剂。这篇综述还强调了对疫苗干燥中各种技术挑战的比较研究，以支持当前受 COVID19 影响的全球健康状况。