Abstract

Potentiometry is extensively studied by researchers as one of the electrochemical methods due to its multiple advantages. Until today, thousands of potentiometric sensors have been developed and applied successfully in many fields such as medicine, environmental monitoring, agriculture, industry and pharmaceutical sciences. Clinical drug analyses and determination of drugs in biological samples are highly important from a medical point of view. These analyses are carried out using various analytical devices including potentiometric sensors. These potentiometric sensors are superior to other devices in terms of several performance parameters, and thus present a good alternative for researchers. Using potentiometric sensors, very successful results in the identification of drug molecules in body fluids have been obtained and reported in the literature up to now. In this study, we review potentiometry-based sensors developed for the determination of drug molecules in various biological samples such as blood serum and urine, and touch upon their performance features in these applications.

摘要

电位法由于其多种优点而被研究人员广泛研究为电化学方法之一。直到今天，成千上万的电位传感器已被开发并成功应用于许多领域，例如医学、环境监测、农业、工业和制药科学。从医学的角度来看，临床药物分析和生物样品中药物的测定非常重要。这些分析是使用包括电位传感器在内的各种分析设备进行的。这些电位传感器在几个性能参数方面优于其他设备，因此为研究人员提供了一个很好的选择。使用电位传感器，迄今为止，在体液中药物分子的鉴定方面取得了非常成功的结果，并在文献中得到报道。在本研究中，我们回顾了为测定血清和尿液等各种生物样品中的药物分子而开发的基于电位计的传感器，并探讨了它们在这些应用中的性能特点。