Abstract

Phthalates are primary industrial chemicals used as polyvinyl chloride (PVC) plasticizers. However, certain phthalates are controlled as restricted substances listed under Annex II of Directive 2011/65/EU, (EU)2015/863. Since an accurate quantification of phthalates is essential to monitoring their concentration levels, quality assurance during their analyses using certified reference materials (CRMs) is required. A PVC CRM for the quantification of phthalates (NMIJ CRM 8152) was provided by the National Metrology Institute of Japan. This CRM was in the form of grayish-white pellets (3-mm diameter × 3-mm length). The analytical procedures adopted were isotope-dilution mass spectrometry, which was the primary method of measurement, and gas chromatography/mass spectrometry; these procedures were optimized and applied to the characterization. The mass fractions of five target phthalates calculated using the mean values were determined as the certified values of the CRM. The relative standard uncertainties attributed to the certification were combined, e.g., those for the characterization, inhomogeneity, and instability. The mass fractions of five phthalates were certified, and those of three phthalates and one adipate were acquired and are reported as technical information. The CRM is shown to be applicable to assessing the validity of analytical methods during the quantification of phthalates in PVC resin and similar materials.

摘要

邻苯二甲酸盐是用作聚氯乙烯（PVC）增塑剂的主要工业化学品。但是，某些邻苯二甲酸盐是根据指令2011/65 / EU（EU）2015/863的附件II列出的受限物质进行管制的。由于邻苯二甲酸盐的准确定量对于监控其浓度水平至关重要，因此需要使用认证的参考物质（CRM）进行邻苯二甲酸盐分析期间的质量保证。日本国立计量学会提供了一种用于定量邻苯二甲酸盐的PVC CRM（NMIJ CRM 8152）。此CRM呈灰白色颗粒形式（直径3毫米×长度3毫米）。所采用的分析程序为同位素稀释质谱法（其为主要测量方法）和气相色谱/质谱法；这些程序已优化并应用于表征。使用平均值计算的五种目标邻苯二甲酸酯的质量分数被确定为CRM的认证值。归因于认证的相对标准不确定度，例如特征，不均匀性和不稳定性的不确定度相结合。认证了5种邻苯二甲酸酯的质量分数，并获得了3种邻苯二甲酸酯和1种己二酸酯的质量分数，并将其报告为技术信息。该CRM被证明可用于评估PVC树脂和类似材料中邻苯二甲酸酯定量过程中分析方法的有效性。和不稳定。认证了5种邻苯二甲酸酯的质量分数，并获得了3种邻苯二甲酸酯和1种己二酸酯的质量分数，并将其报告为技术信息。该CRM被证明可用于评估PVC树脂和类似材料中邻苯二甲酸酯定量过程中分析方法的有效性。和不稳定。认证了5种邻苯二甲酸酯的质量分数，并获得了3种邻苯二甲酸酯和1种己二酸酯的质量分数，并将其报告为技术信息。该CRM被证明可用于评估PVC树脂和类似材料中邻苯二甲酸酯定量过程中分析方法的有效性。