For patients with end-stage lung disease, lung transplantation is a lifesaving therapy. Currently however, the number of patients which require a transplant exceed the number of donor lungs available. One of the contributing factors to this is the conservative mindset of physicians whom are concerned about transplanting marginal lungs due to the potential risk of primary graft dysfunction. Ex vivo lung perfusion (EVLP) technology has allowed for the expansion of donor pool of organs by enabling assessment and reconditioning of these marginal grafts prior to transplant. Ongoing efforts to optimize the therapeutic potential of EVLP are underway. Researchers have adopted the use of different large and small animal models to generate translational pre-clinical data. This includes the use of rejected human lungs, pig lungs, and rat lungs. In this review, we summarize some of the key current literatures relevant to each of the major EVLP model platform, and identify the advantages and disadvantages of each platform. The review aims to guide investigators in choosing appropriate species model to suit their specific goals of study, and ultimately aid in translation of therapy to meet the growing needs of the patient population.

中文翻译：

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活体肺灌注用于供体肺的评估和修复：跨物种间模型的回顾。

对于终末期肺部疾病的患者，肺移植是一种挽救生命的疗法。然而，当前，需要移植的患者数量超过了可用的供体肺的数量。造成这种情况的因素之一是医师的保守态度，他们担心由于原发性移植物功能障碍的潜在风险而移植边缘肺。体外肺灌注（EVLP）技术通过在移植前评估和修复这些边缘移植物，从而扩大了器官供体库。正在努力优化EVLP的治疗潜力。研究人员已经采用了不同的大型和小型动物模型来生成翻译前临床数据。这包括使用被拒绝的人肺，猪肺和大鼠肺。在这篇综述中，我们总结了与每个主要EVLP模型平台相关的一些关键当前文献，并确定了每个平台的优缺点。该综述旨在指导研究人员选择适合其特定研究目标的合适物种模型，并最终帮助翻译治疗方法以满足患者人群不断增长的需求。