TGF‐β/Smad2 signalling regulates enchondral bone formation of Gli1 + periosteal cells during fracture healing,Cell Proliferation

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TGF‐β/Smad2 signalling regulates enchondral bone formation of Gli1 + periosteal cells during fracture healing
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-09-30 , DOI: 10.1111/cpr.12904
Chenjie Xia _{1,

2,

3} , Qinwen Ge _{1,

2} , Liang Fang _{1,

2} , Huan Yu _{1,

2} , Zhen Zou _{1,

2} , Peng Zhang _{1,

2} , Shuaijie Lv ₄ , Peijian Tong ₄ , Luwei Xiao ₁ , Di Chen ₅ , Ping‐er Wang ₁ , Hongting Jin ₁

Affiliation

Most bone fracture heals through enchondral bone formation that relies on the involvement of periosteal progenitor cells. However, the identity of periosteal progenitor cells and the regulatory mechanism of their proliferation and differentiation remain unclear. The aim of this study was to investigate whether Gli1‐CreERT2 can identify a population of murine periosteal progenitor cells and the role of TGF‐β signalling in periosteal progenitor cells on fracture healing.

中文翻译：

TGF-β/Smad2 信号调节骨折愈合过程中 Gli1 + 骨膜细胞的软骨内骨形成

大多数骨折通过依赖于骨膜祖细胞参与的软骨内骨形成而愈合。然而，骨膜祖细胞的身份及其增殖和分化的调节机制仍不清楚。本研究的目的是研究 Gli1-CreERT2 是否可以识别小鼠骨膜祖细胞群，以及 TGF-β 信号在骨膜祖细胞中对骨折愈合的作用。

更新日期：2020-09-30

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