One‐Pot Mannich, Aza‐Wittig and Dehydrofluorinative Aromatization Reactions for Direct Synthesis of 2,3‐Disubstituted 4‐Aminoquinolines,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

One‐Pot Mannich, Aza‐Wittig and Dehydrofluorinative Aromatization Reactions for Direct Synthesis of 2,3‐Disubstituted 4‐Aminoquinolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-09-29 , DOI: 10.1002/adsc.202000734
Xiaofeng Zhang ₁ , Xiaoming Ma ₂ , Weiqi Qiu ₃ , John Mark Awad ₃ , Jason Evans ₃ , Wei Zhang ₃

Affiliation

One‐pot synthesis of 2,3‐disubstituted 4‐aminoquinolines is developed through a three‐component reaction of 2‐azidobenzaldehydes, α‐fluoro‐β‐ketoesters and amines involving cascade Mannich, aza‐Wittig and dehydrofluorinative aromatization. The method is applicable to other functionalized quinolines. It is a pot, atom and step economy (PASE) synthesis of biologically interesting 4‐aminoquinolines relevant to hydroxychloroquine and chloroquine.

中文翻译：

直接合成2,3-二取代的4-氨基喹啉的一锅曼尼希，氮杂-维蒂希和脱氟化氢芳香化反应

通过2-叠氮苯甲醛，α-氟-β-酮酸酯和胺的三组分反应（包括级联曼尼希，氮杂-维蒂希和脱氟化氢芳构化）开发了2，3-二取代的4-氨基喹啉的一锅合成方法。该方法适用于其他官能化喹啉。这是一种与羟氯喹和氯喹相关的，具有生物学意义的4-氨基喹啉的锅，原子和步经济（PASE）合成。

更新日期：2020-12-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11