Application of Bioavailability Models to Derive Chronic Guideline Values for Nickel in Freshwaters of Australia and New Zealand,Environmental Toxicology and Chemistry

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Application of Bioavailability Models to Derive Chronic Guideline Values for Nickel in Freshwaters of Australia and New Zealand
Environmental Toxicology and Chemistry ( IF 3.6 ) Pub Date : 2020-09-30 , DOI: 10.1002/etc.4885
Jenny Stauber ₁ , Lisa Golding ₁ , Adam Peters ₂ , Graham Merrington ₂ , Merrin Adams ₁ , Monique Binet ₁ , Graeme Batley ₁ , Francesca Gissi ₃ , Kitty McKnight ₁ , Emily Garman ₄ , Ellie Middleton ₄ , Jennifer Gadd ₅ , Chris Schlekat ₄

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There has been an increased emphasis on incorporating bioavailability‐based approaches into freshwater guideline value derivations for metals in the Australian and New Zealand water quality guidelines. Four bioavailability models were compared: the existing European biotic ligand model (European Union BLM) and a softwater BLM, together with 2 newly developed multiple linear regressions (MLRs)—a trophic level‐specific MLR and a pooled MLR. Each of the 4 models was used to normalize a nickel ecotoxicity dataset (combined tropical and temperate data) to an index condition of pH 7.5, 6 mg Ca/L, 4 mg Mg/L, (i.e., approximately 30 mg CaCO₃/L hardness), and 0.5 mg DOC/L. The trophic level‐specific MLR outperformed the other 3 models, with 79% of the predicted 10% effect concentration (EC10) values within a factor of 2 of the observed EC10 values. All 4 models gave similar normalized species sensitivity distributions and similar estimates of protective concentrations (PCs). Based on the index condition water chemistry proposed as the basis of the national guideline value, a protective concentration for 95% of species (PC95) of 3 µg Ni/L was derived. This guideline value can be adjusted up and down to account for site‐specific water chemistries. Predictions of PC95 values for 20 different typical water chemistries for Australia and New Zealand varied by >40‐fold, which confirmed that correction for nickel bioavailability is critical for the derivation of site‐specific guideline values. Environ Toxicol Chem 2021;40:100–112. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

中文翻译：

应用生物利用度模型推导出澳大利亚和新西兰淡水中镍的慢性指导值

在澳大利亚和新西兰水质准则中，越来越重视将基于生物利用度的方法纳入金属的淡水准则值推导中。比较了四种生物利用度模型：现有的欧洲生物配体模型（欧盟 BLM）和软水 BLM，以及 2 个新开发的多元线性回归（MLR）——营养水平特异性 MLR 和混合 MLR。4 个模型中的每一个都用于将镍生态毒性数据集（结合热带和温带数据）标准化为 pH 7.5、6 mg Ca/L、4 mg Mg/L（即约 30 mg CaCO ₃/L 硬度）和 0.5 mg DOC/L。营养水平特定的 MLR 优于其他 3 个模型，79% 的预测 10% 效应浓度 (EC10) 值在观察到的 EC10 值的 2 倍以内。所有 4 个模型都给出了相似的归一化物种敏感性分布和相似的保护浓度 (PC) 估计值。根据作为国家指导值基础提出的指标条件水化学，推导出对 95% 物种 (PC95) 的保护浓度为 3 µg Ni/L。该准则值可以上下调整，以考虑特定地点的水化学。澳大利亚和新西兰 20 种不同典型水化学物质的 PC95 值的预测变化 > 40 倍，环境毒理学化学2021；40：100–112。© 2020 作者。环境毒理学和化学由 Wiley Periodicals LLC 代表 SETAC 出版。

更新日期：2020-09-30

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