OBJECTIVE Micro-nutrients are closely related to pulmonary tuberculosis (PTB). Most patients with PTB suffer from micro-nutrients deficiency. We aimed to evaluate the efficacy of micro-nutrients support on clinical therapy and chronic inflammation in patients with PTB. METHODS We searched Pubmed, Springer link, Web of Science, Cochrane, Wan Fang and CNKI databases for randomised controlled trials (RCTs). The patients with anti-TB treatments were divided into two groups, the control group with nutritional advice or placebo, and the experimental group with micro-nutrients support for more than 2 weeks. Two reviewers conducted data extraction and quality assessment of the studies independently, and ReviewManager 5.2 software was used to input and analyse the data. The dichotomous variable was expressed in the risk ratios (RRS) and 95% CI, the continuous data were expressed in the mean difference (MD) and 95% CI, and the heterogeneity of subgroup was evaluated by I (Kerantzas and Jacobs, Jr., 2017) [2] test. RESULTS A total of 13 trials (2847 participants) were included. First, micro-nutrients improved sputum smears or culture negative conversion rates (OR 0.16 0.03-0.77, 2.29; MD -2.36, -4.72~-0.01, z = 1.97). Meanwhile, micro-nutrients support increased lymphocytes and decreased leukocytes, neutrophils, CRP and ESR (MD 0.20, 0.06-0.35, z = 2.78; MD -0.42, -0.65~-0.18, z = 3.48; MD -0.66, -1.12~-0.20, z = 2.82). However it had not impact on body weight, MUAC, haemoglobin, albumin or monocytes (p > 0.05). CONCLUSION Micro-nutrients support can reduce chronic inflammation and improve sputum smears or culture conversions to contribute to anti-TB treatment.

中文翻译：

---

微量营养素对肺结核患者营养不良、免疫和治疗效果的影响：随机对照试验的系统评价和荟萃分析

目的微量营养素与肺结核（PTB）密切相关。大多数PTB患者患有微量营养素缺乏症。我们旨在评估微量营养素支持对 PTB 患者的临床治疗和慢性炎症的疗效。方法 我们在 Pubmed、Springer link、Web of Science、Cochrane、Wan Fang 和 CNKI 数据库中搜索随机对照试验 (RCT)。接受抗结核治疗的患者分为两组，对照组给予营养建议或安慰剂，实验组给予微量营养素支持2周以上。两名评价员独立对研究进行数据提取和质量评估，使用ReviewManager 5.2软件进行数据录入和分析。二分变量以风险比 (RRS) 和 95% CI 表示，连续数据用平均差（MD）和95% CI表示，亚组异质性用I（Kerantzas and Jacobs, Jr., 2017）[2]检验评价。结果 共纳入 13 项试验（2847 名参与者）。首先，微量营养素改善了痰涂片或培养阴性转化率（OR 0.16 0.03-0.77, 2.29; MD -2.36, -4.72~-0.01, z = 1.97）。同时，微量营养素支持淋巴细胞增加，白细胞、中性粒细胞、CRP和ESR减少（MD 0.20, 0.06-0.35, z = 2.78; MD -0.42, -0.65~-0.18, z = 3.48; MD -0.66, -1.12~ -0.20，z = 2.82）。然而，它对体重、MUAC、血红蛋白、白蛋白或单核细胞没有影响（p > 0.05）。结论 微量营养素支持可以减少慢性炎症并改善痰涂片或培养转化，从而有助于抗结核治疗。