Mitigating climate change is a key driver for the development of sustainable and CO₂-neutral production processes. In this regard, connecting carbon capture and utilization processes to derive microbial C₁ fermentation substrates from CO₂ is highly promising. This strategy uses methylotrophic microbes to unlock next-generation processes, converting CO₂-derived methanol. Synthetic biology approaches in particular can empower synthetic methylotrophs to produce a variety of commodity chemicals. We believe that yeasts have outstanding potential for this purpose, because they are able to separate toxic intermediates and metabolic reactions in organelles. This compartmentalization can be harnessed to design superior synthetic methylotrophs, capable of utilizing methanol and other hitherto largely disregarded C₁ compounds, thus supporting the establishment of a future circular economy.

减缓气候变化是发展可持续和 CO ₂中性生产过程的关键驱动因素。在这方面，连接碳捕获和利用过程以从 CO _{2 中}获得微生物 C ₁发酵底物是非常有前途的。该策略使用甲基营养微生物来解锁下一代过程，将 CO ₂-衍生的甲醇。特别是合成生物学方法可以使合成甲基营养生物产生各种商品化学品。我们相信酵母在此方面具有出色的潜力，因为它们能够分离细胞器中的有毒中间体和代谢反应。这种划分可以用来设计高级合成甲基营养菌，能够利用甲醇和其他迄今为止在很大程度上被忽视的 C ₁化合物，从而支持未来循环经济的建立。