Tissue-resident memory (T_RM) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. T_RM- like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. T_RM cells have also been shown to mediate anti-tumor immunity in murine models. Biology of T_RM cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of T_RM T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.

组织驻留记忆 (T _RM ) T 细胞是不同的非循环淋巴细胞群，在介导区域免疫中起重要作用。Ť _RM -样细胞已被识别出在几个人肿瘤肿瘤浸润淋巴细胞的分量和关联与结果和响应于免疫疗法。T _RM细胞也已显示在鼠模型中介导抗肿瘤免疫。T _RM细胞的生物学对临床癌症免疫治疗有多种影响。在这里，我们讨论了新的见解T的生物学_RM T 细胞并讨论它们对理解肿瘤免疫微环境异质性以及提高癌症疫苗、免疫检查点阻断和过继细胞疗法在临床中的功效的意义。