Abomasal hypomotility is one of the important causes of neonatal mortality in small ruminants. Various pharmaceutical agents have been studied to address this problem in large ruminants. The aim of this study was to determine the effect of parenteral administration of tylosin and ivermectin on abomasal emptying rate in neonatal suckling lambs. Abomasal emptying rate was assessed using nuclear scintigraphic method in 10 healthy female Iranian fat tailed Ghezel lambs. Each lamb was tested three times, once as a control (1 ml of saline 0.9%, IM) and twice after the injection of tylosin (17.6 mg/kg, IM) and ivermectin (200 μg/kg, SC) in a crossover study. Based on radiopharmaceutical counts, remnant activity in abomasums at 90 min were 48.3 ± 3.5, 45.6 ± 7.5 and 41.6 ± 2.9% in control, tylosin and ivermectin groups, respectively. Administration of tylosin (p = 0.049) and ivermectin (p = 0.045) to lambs, significantly caused faster abomasal emptying rate compared to control. Evaluating the ROIs revealed that the half emptying time (T_1/2) in control, tylosin and ivermectin groups were 67.1 ± 8.6, 62.6 ± 14.2 and 54.3 ± 9.9 min, respectively. These difference between all groups, statistically were significant (p = 0.026). However, the clinical efficacy of abomasal emptying rate facilitating by tylosin or ivermectin administration in lambs remains to be determined.

异常反刍是小反刍动物新生儿死亡的重要原因之一。已经研究了各种药剂来解决大型反刍动物中的这个问题。这项研究的目的是确定泰乐菌素和伊维菌素的肠胃外给药对新生乳羊羔腹部排空率的影响。使用核闪烁显像法评估了10头健康的伊朗雌性脂肪尾Ghezel羔羊的反胃排空率。在交叉研究中，对每只羊羔进行了3次测试，一次作为对照（1 ml生理盐水0.9％，IM），两次注射泰乐菌素（17.6 mg / kg，IM）和伊维菌素（200μg/ kg，SC）后进行两次测试。根据放射性药物计数，对照组，泰乐菌素组和伊维菌素组在90分钟时的厌氧菌残留活性分别为48.3±3.5％，45.6±7.5和41.6±2.9％。p  = 0.049）和伊维菌素（p  = 0.045）致羔羊，与对照组相比，明显导致了更快的腹部排空率。对ROI的评估显示，对照组，泰乐菌素和伊维菌素组的半空时间（T _1/2）分别为67.1±8.6、62.6±14.2和54.3±9.9分钟。所有组之间的这些差异在统计学上都是显着的（p  = 0.026）。然而，通过在羊羔中施用泰乐菌素或伊维菌素促进的产前排空率的临床疗效尚待确定。