The effect of pregnancy hormone estriol (E3) on innate and adaptive immunity cells functions in patients with multiple sclerosis (MS) in comparison with healthy donors (HD) was studied. E3 inhibited phagocytic activity of neutrophils and enhanced monocytes IDO activity. Treg percentage increased and number of Th17 and iNKT cells decreased under E3 influence. At the same time, E3 stimulated production of IL-10 and inhibited secretion of IL-17. The hormonal effects were realized on the cells of both HD and MS patients. Thus, the MS amelioration during pregnancy may be related to E3 influence.

中文翻译：

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雌三醇在多发性硬化症中调节细胞介导的免疫反应

研究了与健康供体 (HD) 相比，妊娠激素雌三醇 (E3) 对多发性硬化症 (MS) 患者先天性和适应性免疫细胞功能的影响。E3 抑制嗜中性粒细胞的吞噬活性并增强单核细胞的 IDO 活性。在 E3 的影响下，Treg 百分比增加，Th17 和 iNKT 细胞数量减少。同时，E3刺激IL-10的产生并抑制IL-17的分泌。对 HD 和 MS 患者的细胞都实现了激素效应。因此，妊娠期 MS 的改善可能与 E3 的影响有关。