Urinary tract infections represent common nosocomial infectious diseases. Bacteriocin production has been recently described as a putative virulence factor in these infections but studies focusing particularly on Pseudomonas aeruginosa are not available. Therefore, we assessed the prevalence of the bacteriocin genes, their co-occurrence and their co-association with previously detected virulence factors in a set of 135 P. aeruginosa strains from catheter-associated urinary tract infections (CAUTIs). The overall bacteriocinogeny reached 96.3 % with an average of 3.6 genes per strain. The most frequently detected determinants were the encoded pyocins S4 (76.3 %), R (69.6 %), and S2 (67.4 %). A statistically significant co-occurrence and a negative relationship were observed between several pyocin types. Particular pyocins exhibited associations with biofilm formation, production of pyochelin, pyocyanin, antibiotic-degrading enzymes, overall strain susceptibility and resistance, and motility of the strain. Co-occurrence of the pyocins S2 and S4 (p<<0.0001; Z = 13.15), both utilizating the ferripyoverdine receptor FpvAI, was found but no relation to pyoverdine production was detected. A negative association (p = 0.0047; Z=-2.83) was observed between pyochelin and pyocin S5 utilising the ferripyochelin receptor FptA. Pairwise assays resulted in 52.1 % inhibition which was equally distributed between soluble and particle types of antimicrobials. In conclusion, pyocin determinants appear to be important characteristics of CAUTI-related P. aeruginosa isolates and could contribute to their urovirulence.

尿路感染代表常见的医院传染病。近来，细菌素的生产已被描述为这些感染中的假定毒力因子，但尚无专门针对铜绿假单胞菌的研究。因此，我们评估了135种铜绿假单胞菌中细菌素基因的普遍性，它们的共现性以及它们与先前检测到的毒力因子的关联性。导管相关性尿路感染（CAUTIs）引起的毒株。总体细菌致癌性达到96.3％，每个菌株平均3.6个基因。最常检测到的决定因素是编码的胞浆球蛋白S4（76.3％），R（69.6％）和S2（67.4％）。在几种脓毒症类型之间观察到统计学上显着的同时发生，并且具有负相关关系。特定的球藻蛋白酶表现出与生物膜的形成，pychelin，pyocyanin的产生，抗生素降解酶，整体菌株的敏感性和耐药性以及菌株的运动性相关。发现均利用铁氧嘧啶过氧化物受体FpvAI的胞嘧啶S2和S4共存（p ＜< 0.0001； Z ＝ 13.15），但未检测到与嘧啶的产生有关。负关联（p = 0.0047; Z = -2。利用铁磷脂酰肌醇蛋白受体FptA观察到了在卵磷脂和脓素S5之间的83）。配对分析产生52.1％的抑制作用，该抑制作用平均分布在可溶性和颗粒型抗菌剂之间。总之，黄霉素决定簇似乎是与CAUTI相关的重要特征铜绿假单胞菌分离株，可能有助于其尿毒力。