This study aimed to explore the correlations of promoter methylation and single-nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (BDNF) with post-traumatic stress disorder (PTSD) in Li and Han nationalities in Hainan province. Depression- and anxiety-related questionnaires were performed for PTSD-related information collection and analysis, with 164 PTSD patients and 141 healthy controls included. Serum BDNF level was measured and the methylation of BDNF promoter was evaluated. The BDNF SNP genotyping was performed, after which the risk genotypes for PTSD were detected and analyzed using logistic regression analysis. Our study found that the PTSD incidence was different in Li and Han nationalities. Serum BDNF level in PTSD patients in Li nationality was obviously lower than that in patients in Han nationality, while the methylation of BDNF promoter was higher in patients in Li nationality. The G-712A rather than rs6265 genotypes presented significant difference between PTSD patients and healthy controls. Meanwhile, the patients in Li nationality with AG genotype at G-712A inclined to depression, and patients with GG genotype had a greater degree of PTSD. G-712A and promoter methylation of BDNF were independent risk factors for PTSD. Our study demonstrated that the differences of PTSD patients between Li and Han nationalities were attributed by SNP G-712A genotypes and promoter methylation of BDNF.

本研究旨在探讨海南黎族和汉族人脑源性神经营养因子（BDNF）的启动子甲基化和单核苷酸多态性（SNP）与创伤后应激障碍（PTSD）的相关性。进行了与抑郁和焦虑相关的问卷调查，以收集和分析与PTSD相关的信息，其中包括164位PTSD患者和141位健康对照。测量血清BDNF水平并评估BDNF启动子的甲基化。进行BDNF SNP基因分型，然后检测PTSD的风险基因型并使用逻辑回归分析进行分析。我们的研究发现，黎族和汉族的PTSD发病率有所不同。黎族PTSD患者的血清BDNF水平明显低于汉族患者，黎族患者BDNF启动子甲基化较高。G-712A基因而非rs6265基因型在PTSD患者和健康对照之间呈现出显着差异。同时，在G-712A有AG基因型的黎族黎族患者倾向于抑郁，而GG基因型患者的PTSD程度较高。G-712A和BDNF启动子甲基化是PTSD的独立危险因素。我们的研究表明，黎族和汉族之间PTSD患者的差异是由SNP G-712A基因型和BDNF启动子甲基化引起的。G-712A区AG基因型的黎族人群倾向于抑郁，GG基因型患者的PTSD程度较高。G-712A和BDNF启动子甲基化是PTSD的独立危险因素。我们的研究表明，黎族和汉族之间PTSD患者的差异是由SNP G-712A基因型和BDNF启动子甲基化引起的。G-712A区AG基因型的黎族人群倾向于抑郁，GG基因型患者的PTSD程度较高。G-712A和BDNF启动子甲基化是PTSD的独立危险因素。我们的研究表明，黎族和汉族之间PTSD患者的差异是由SNP G-712A基因型和BDNF启动子甲基化引起的。