Copper is an essential trace element required for human life, and is involved in several physiological mechanisms. Today researchers have found and confirmed that Cu has biological properties which are particularly useful for orthopedic biomaterials applications such as implant coatings or biodegradable filler bone substitutes. Indeed, Cu exhibits antibacterial functions, provides angiogenic ability and favors osteogenesis; these represent major key points for ideal biomaterial integration and the healing process that follows. The antibacterial performances of copper-doped biomaterials present an interesting alternative to the massive use of prophylactic antibiotics and help to limit the development of antibiotic resistance. By stimulating blood vessel growth and new bone formation, copper contributes to the improved bio-integration of biomaterials. This review describes the bio-functional advantages offered by Cu and focuses on the antibacterial, angiogenic and osteogenic properties of Cu-doped biomaterials with potential for orthopedic applications.

铜是人类生活中必不可少的微量元素，并参与多种生理机制。如今，研究人员已经发现并证实，铜具有生物学特性，特别适用于整形外科生物材料应用，例如植入物涂层或可生物降解的填充骨替代物。确实，铜表现出抗菌功能，提供血管生成能力并有利于成骨。这些代表了理想的生物材料整合和随后的愈合过程的主要关键点。铜掺杂生物材料的抗菌性能是大规模使用预防性抗生素的有趣替代方法，有助于限制抗生素耐药性的发展。通过刺激血管生长和新骨形成，铜有助于改善生物材料的生物整合。这篇综述描述了铜提供的生物功能优势，并着重介绍了铜掺杂生物材料的抗菌，血管生成和成骨特性，具有骨科应用潜力。