This article is a tribute to Eli Sercarz and draws on his proposal of a hierarchical order of T-cell determinants in antigen presentation and T-cell activation. Here I revisit the concept of dominance and crypticity in the context of lymphocyte cooperation in the generation of the adaptive immune response, with emphasis on Th-Th cooperation. The remarks made in this article serve as a basis for a reassessment of the unresponsiveness of self-tumor antigens and how to leverage cryptic T-cell determinants operationally to generate antitumor T-cell immunity.

中文翻译：

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 乌比·马约尔·小塞萨特


本文向 Eli Sercarz 致敬，并借鉴了他提出的抗原呈递和 T 细胞激活中 T 细胞决定簇的分层顺序的建议。在这里，我在适应性免疫反应产生过程中淋巴细胞合作的背景下重新审视优势和神秘性的概念，重点是 Th-Th 合作。本文中的评论可作为重新评估自体肿瘤抗原的无反应性以及如何有效利用神秘 T 细胞决定簇来产生抗肿瘤 T 细胞免疫的基础。