Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib,New Journal of Chemistry

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Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020-09-29 , DOI: 10.1039/d0nj03896b
Barbara Vercelli _{1,

2,

3,

4} , Sara Crotti _{4,

5,

6} , Marco Agostini _{4,

5,

6,

7,

8}

Affiliation

The voltammetric responses of two anticancer molecules irinotecan (ITC) and sunitinib (SUN) were investigated at glassy carbon (GC) and indium tin oxide (ITO) electrodes bare or modified with carbon nanotubes (NTs), NT–Nafion composites (NafionNTs) and poly(3,4-ethylenedioxy-thiophene) (PEDOT). Bare GC electrodes revealed to be the most suitable for the detection of drugs at low concentration levels. Differential pulse voltammetry (DPV) analyses showed that the responses of the anticancer molecules are affected by the formation of aggregates. In particular, aggregation of SUN results in the formation of H-aggregates. DPV analysis extended to human plasma samples revealed the drugs in micromolar concentrations with good reproducibility.

中文翻译：

修饰电极上的伏安响应和两种抗癌分子：伊立替康和舒尼替尼的聚集效应

研究了两种裸露的或修饰有碳纳米管（NTs），NT–Nafion复合材料（NafionNTs）和碳纳米管的玻碳（GC）和氧化铟锡（ITO）电极上两种抗癌分子伊立替康（ITC）和舒尼替尼（SUN）的伏安响应。聚（3,4-乙撑二氧噻吩）（PEDOT）。裸露的GC电极显示最适合于低浓度水平的药物检测。差示脉冲伏安法（DPV）分析表明，抗癌分子的反应受聚集体形成的影响。特别地，SUN的聚集导致H聚集的形成。对人血浆样品进行的DPV分析表明，该药物的浓度为微摩尔浓度，具有良好的重现性。

更新日期：2020-10-19

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