The meniscus plays a critical role in maintaining knee joint homeostasis. Injuries to the meniscus, especially considering the limited self-healing capacity of the avascular region, continue to be a challenge and are often treated by (partial) meniscectomy, which has been identified to cause osteoarthritis. Currently, meniscus tissue engineering focuses on providing extracellular matrix (ECM)-mimicking scaffolds to direct the inherent meniscal regeneration process, and it has been found that various stimuli are essential. Numerous bioactive factors present benefits in regulating cell fate, tissue development, and healing, but lack an optimal delivery system. More recently, bioengineers have developed various polymer-based drug delivery systems (PDDSs), which are beneficial in terms of the favorable properties of polymers as well as novel delivery strategies. Engineered PDDSs aim to provide not only an ECM-mimicking microenvironment but also the controlled release of bioactive factors with release profiles tailored according to the biological concerns and properties of the factors. In this review, both different polymers and bioactive factors involved in meniscal regeneration are discussed, as well as potential candidate systems, with examples of recent progress. This article aims to summarize drug delivery strategies in meniscal regeneration, with a focus on novel delivery strategies rather than on specific delivery carriers. The current challenges and future prospects for the structural and functional regeneration of the meniscus are also discussed.

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用于半月板再生的基于聚合物的先进药物递送策略

半月板在维持膝关节稳态方面起着关键作用。半月板损伤，特别是考虑到无血管区域的自愈能力有限，仍然是一个挑战，通常通过（部分）半月板切除术治疗，这已被确定为导致骨关节炎。目前，半月板组织工程的重点是提供细胞外基质 (ECM) 模拟支架来指导固有的半月板再生过程，并且已经发现各种刺激是必不可少的。许多生物活性因子在调节细胞命运、组织发育和愈合方面具有优势，但缺乏最佳的传递系统。最近，生物工程师开发了各种基于聚合物的药物递送系统 (PDDS)，这在聚合物的有利特性以及新的递送策略方面是有益的。工程化的 PDDS 不仅旨在提供模拟 ECM 的微环境，还旨在提供生物活性因子的受控释放，其释放曲线根据因子的生物学问题和特性量身定制。在这篇综述中，讨论了参与半月板再生的不同聚合物和生物活性因子，以及潜在的候选系统，并举例说明了最近的进展。本文旨在总结半月板再生中的药物递送策略，重点是新的递送策略而不是特定的递送载体。还讨论了半月板结构和功能再生的当前挑战和未来前景。工程化的 PDDS 不仅旨在提供模拟 ECM 的微环境，还旨在提供生物活性因子的受控释放，其释放曲线根据因子的生物学问题和特性量身定制。在这篇综述中，讨论了参与半月板再生的不同聚合物和生物活性因子，以及潜在的候选系统，并举例说明了最近的进展。本文旨在总结半月板再生中的药物递送策略，重点是新的递送策略而不是特定的递送载体。还讨论了半月板结构和功能再生的当前挑战和未来前景。工程化的 PDDS 不仅旨在提供模拟 ECM 的微环境，还旨在提供生物活性因子的受控释放，其释放曲线根据因子的生物学问题和特性量身定制。在这篇综述中，讨论了参与半月板再生的不同聚合物和生物活性因子，以及潜在的候选系统，并举例说明了最近的进展。本文旨在总结半月板再生中的药物递送策略，重点是新的递送策略而不是特定的递送载体。还讨论了半月板结构和功能再生的当前挑战和未来前景。