The environmental species Pseudomonas aeruginosa thrives in a variety of habitats. Within the epidemic population structure of P. aeruginosa, occassionally highly successful clones that are equally capable to succeed in the environment and the human host arise. Framed by a highly conserved core genome, individual members of successful clones are characterized by a high variability in their accessory genome. The abundance of successful clones might be funded in specific features of the core genome or, although not mutually exclusive, in the variability of the accessory genome. In clone C, one of the most predominant clones, the plasmid pKLC102 and the PACGI-1 genomic island are two ubiquitous accessory genetic elements. The conserved transmissible locus of protein quality control (TLPQC) at the border of PACGI-1 is a unique horizontally transferred compository element, which codes predominantly for stress-related cargo gene products such as involved in protein homeostasis. As a hallmark, most TLPQC xenologues possess a core genome equivalent. With elevated temperature tolerance as a characteristic of clone C strains, the unique P. aeruginosa and clone C specific disaggregase ClpG is a major contributor to tolerance. As other successful clones, such as PA14, do not encode the TLPQC locus, ubiquitous denominators of success, if existing, need to be identified.

中文翻译：

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为什么？–成功的铜绿假单胞菌克隆，重点是克隆C

铜绿假单胞菌的环境物种在各种栖息地中繁衍生息。在铜绿假单胞菌的流行种群结构内有时会在环境和人类宿主中获得同样成功的高度成功克隆。以高度保守的核心基因组为框架，成功克隆的各个成员的特征在于其辅助基因组的高度可变性。成功克隆的丰富性可能是由核心基因组的特定特征或辅助基因组的变异性（尽管不是互斥的）提供的。在克隆C（最主要的克隆之一）中，质粒pKLC102和PACGI-1基因组岛是两个普遍存在的辅助遗传元件。PACGI-1边界的蛋白质质量控​​制（TLPQC）保守型可传播基因座是独特的水平转移复合元素，主要编码与应激相关的货物基因产物，例如参与蛋白质稳态的蛋白质。作为标志，大多数TLPQC外源分子都具有核心基因组等效物。耐高温性是克隆C菌株的特征，独特铜绿假单胞菌和克隆C特异的去聚合酶ClpG是耐受性的主要贡献者。由于其他成功的克隆（例如PA14）不编码TLPQC基因座，因此需要确定成功的普遍分母（如果存在）。