BAX and BAK oligomerize to mediate mitochondrial membrane permeabilization during apoptosis. A recent structure of the core domain of active BAK dimers with bound phospholipid molecules reveals a new bridging mechanism by which lipids drive BAX and BAK oligomerization and membrane pore formation.

中文翻译：

---

脂质将 BAK 二聚体粘合在一起

BAX 和 BAK 寡聚化以介导细胞凋亡过程中的线粒体膜透化。具有结合磷脂分子的活性 BAK 二聚体核心域的最新结构揭示了一种新的桥接机制，通过该机制，脂质驱动 BAX 和 BAK 寡聚化以及膜孔形成。