Abstract

Aim

The present study aimed to investigate and compare possible changes in amplitude and latency of pattern visual evoked potentials (PVEP) and thickness of quadrants of the macula (TQM) using optic coherence tomography (OCT).

Materials and Methods

According to polysomnography examinations, 30 mild, 30 severe, 30 controls were included in the study after approval from the ethics committee.

Results

No significant difference was found in age and gender between the groups (p = 0.184 and p = 0.954). Significant difference was found between external and internal superior TQM, mean thickness of ganglion cell layer in comparison of all three groups (p = 0.011, p = 0.047, p = 0.030). In comparison between severe OSAS and control groups, significant difference was found in internal nasal, internal superior and external superior TQM (p = 0.048, p = 0.033, p = 0.014) while no significant difference was found TQM in comparison between the mild OSAS and control groups. In comparison between the group of severe OSAS and controls, significant increase was found in P100 as well as N145 latencies whereas only P100 latency was found to increase when mild OSAS was compared with controls. No significant correlation was found between TQM and PVEP parameters in mild and severe OSAS patients.

Discussion

Latency and amplitude of PVEP altered in OSAS because edema and inflammation was remarkable in mild as well as severe stages of the disease. Furthermore, thinning in the macula was observed only in severe stages of the disease, explained with level of atrophy and exposure to extended hypoxia.

中文翻译：

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撤回文章：在阻塞性睡眠呼吸暂停综合征的不同临床阶段使用光学相干断层扫描和模式视觉诱发电位评估黄斑厚度和视觉通路

摘要

目标

本研究旨在使用光学相干断层扫描 (OCT) 研究和比较模式视觉诱发电位 (PVEP) 和黄斑象限厚度 (TQM) 的幅度和潜伏期的可能变化。

材料和方法

根据多导睡眠图检查，经伦理委员会批准后，30 名轻度、30 名重度、30 名对照被纳入研究。

结果

两组之间的年龄和性别没有显着差异（p  = 0.184 和p  = 0.954）。三组比较，内外优越TQM、神经节细胞层平均厚度有显着差异（p  = 0.011，p  = 0.047，p  = 0.030）。重度OSAS组与对照组比较，鼻内、内上、外上TQM差异显着（p  =0.048，p  =0.033，p = 0.014)，而轻度 OSAS 组和对照组之间的 TQM 没有显着差异。在严重 OSAS 组和对照组之间的比较中，发现 P100 和 N145 潜伏期显着增加，而当与对照组相比时，发现仅 P100 潜伏期增加。轻度和重度 OSAS 患者的 TQM 和 PVEP 参数之间没有显着相关性。

讨论

在 OSAS 中 PVEP 的潜伏期和幅度发生了变化，因为水肿和炎症在疾病的轻度和重度阶段都很显着。此外，仅在疾病的严重阶段观察到黄斑变薄，这可以用萎缩程度和长期缺氧来解释。