Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of Salmonella and at least two other Gram-negative bacteria in vitro. This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria.

中文翻译：

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溶血磷脂酰胆碱增强多粘菌素B的抗菌活性。

多粘菌素B用于治疗由抗生素耐药的革兰氏阴性细菌引起的感染，其当前剂量会产生肾毒性。我们显示该药物和溶血磷脂酰胆碱（LPC）的非杀菌浓度的组合在体外可有效抑制沙门氏菌和至少两种其他革兰氏阴性细菌的生长。这种结合使细菌膜具有多孔性，并导致DnaK（蛋白质折叠的调节剂）降解。多粘菌素B-LPC组合可能是一种抗药细菌的有效且安全的方案。