Cognitive inhibition has been suggested to deteriorate in Alzheimer’s disease. While numerous studies with different experimental paradigms found evidence on impaired inhibition in attention and memory, evidence in favour of intact memory inhibition has been reported with regard to the phenomenon of retrieval-induced forgetting (Moulin et al., 2002). Here, we adapted the previously used paradigm in order to reduce the contribution of non-inhibitory processes and examined whether retrieval-induced forgetting could still be observed in a sample of participants with diagnosed Alzheimer’s disease. In contrast to the previous finding, we found that retrieval-induced forgetting only occurred in an age-matched control group. These results suggest that inhibitory deficits in Alzheimer’s disease also generalize to memory inhibition that resolves interference occurring during retrieval, whereas effects of retrieval-induced forgetting may still occur when non-inhibitory causes, such as, blocking by previously retrieved content, are not precluded.

中文翻译：

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阿尔茨海默病型痴呆的记忆抑制中断

已经提出认知抑制在阿尔茨海默病中恶化。虽然使用不同实验范式的大量研究发现了注意力和记忆力抑制受损的证据，但已经报道了关于检索诱发遗忘现象的有利于完整记忆抑制的证据（Moulin 等，2002）。在这里，我们调整了以前使用的范式以减少非抑制过程的贡献，并检查在诊断出的阿尔茨海默病的参与者样本中是否仍然可以观察到检索引起的遗忘。与之前的发现相反，我们发现检索诱发的遗忘仅发生在年龄匹配的对照组中。