ROPs are molecular switches controlling diverse cellular and developmental processes. In this issue, Ge et al. (pp. 1484–1499) report that ROPs are targeted to the plasma membrane not only through the activity of RhoGDIs but also directly by vesicular trafficking, involving COPII, ARF1, AP‐1, and sterols. RhoGDIs and the vesicular trafficking route synergistically mediate ROP targeting and thus cell polarization.

中文翻译：

---

封面图片：ROP2被隔离在Sar1DN标记的ER-高尔基囊泡中

ROP是控制各种细胞和发育过程的分子开关。在这个问题上，Ge等。（pp。1484–1499）报告ROP不仅通过RhoGDI的活性靶向质膜，还直接通过涉及COPII，ARF1，AP-1和固醇的囊泡贩运而靶向。RhoGDI和水泡运输途径协同介导ROP靶向，从而细胞极化。