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Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-09-29 , DOI: 10.1111/cns.13457 Song Ta 1, 2 , Xianfang Rong 2 , Zhen-Ni Guo 1 , Hang Jin 1 , Peng Zhang 1 , Fenge Li 1 , Zhihuan Li 3 , Lilong Lin 3 , Chenqing Zheng 4 , Qingquan Gu 4 , Yuan Zhang 5 , Wenlan Liu 5 , Yi Yang 1 , Junlei Chang 2
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-09-29 , DOI: 10.1111/cns.13457 Song Ta 1, 2 , Xianfang Rong 2 , Zhen-Ni Guo 1 , Hang Jin 1 , Peng Zhang 1 , Fenge Li 1 , Zhihuan Li 3 , Lilong Lin 3 , Chenqing Zheng 4 , Qingquan Gu 4 , Yuan Zhang 5 , Wenlan Liu 5 , Yi Yang 1 , Junlei Chang 2
Affiliation
The canonical Wnt signaling pathway plays an essential role in blood‐brain barrier integrity and intracerebral hemorrhage in preclinical stroke models. Here, we sought to explore the association between canonical Wnt signaling and hemorrhagic transformation (HT) following intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients as well as to determine the underlying cellular mechanisms.
中文翻译：
WNT7A 和 GPR124 的变异与缺血性中风静脉溶栓后的出血转化相关
经典 Wnt 信号通路在临床前中风模型中的血脑屏障完整性和脑出血中发挥着重要作用。在这里，我们试图探索急性缺血性卒中（AIS）患者静脉溶栓（IVT）后经典Wnt信号传导与出血转化（HT）之间的关联，并确定潜在的细胞机制。
更新日期：2020-09-29
中文翻译：
WNT7A 和 GPR124 的变异与缺血性中风静脉溶栓后的出血转化相关
经典 Wnt 信号通路在临床前中风模型中的血脑屏障完整性和脑出血中发挥着重要作用。在这里，我们试图探索急性缺血性卒中（AIS）患者静脉溶栓（IVT）后经典Wnt信号传导与出血转化（HT）之间的关联，并确定潜在的细胞机制。
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