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Monitoring the three‐dimensional distribution of endogenous species in the lungs by matrix‐assisted laser desorption/ionization mass spectrometry imaging
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-09-29 , DOI: 10.1002/rcm.8957
Bryn Flinders 1, 2, 3 , Josie Morrell 4 , Peter S Marshall 4 , Lisa E Ranshaw 4 , Ron M A Heeren 3 , Malcolm R Clench 1
Affiliation  

Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) is routinely employed to monitor the distribution of compounds in tissue sections and generate two‐dimensional (2D) images. Whilst informative the images do not represent the distribution of the analyte of interest through the entire organ. The generation of 3D images is an exciting field that can provide a deeper view of the analyte of interest throughout an entire organ.

中文翻译:

通过基质辅助激光解吸/电离质谱成像监测肺部内源性物质的三维分布

基质辅助激光解吸/电离质谱成像 (MALDI-MSI) 通常用于监测组织切片中化合物的分布并生成二维 (2D) 图像。虽然信息丰富,但图像并不代表感兴趣的分析物在整个器官中的分布。3D 图像的生成是一个令人兴奋的领域,它可以提供整个器官中感兴趣分析物的更深入视图。
更新日期:2020-11-05
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