Factors inducing transdifferentiation of myoblasts into adipocytes,Journal of Cellular Physiology

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Factors inducing transdifferentiation of myoblasts into adipocytes
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-09-28 , DOI: 10.1002/jcp.30074
Liyi Wang _{1,

2,

3} , Tizhong Shan _{1,

2,

3}

Affiliation

Fat infiltration in skeletal muscle is observed in several myopathies, is associated with muscular dysfunction, and is strongly correlated with insulin resistance, diabetes, obesity, and aging. In animal production, skeletal muscle fat (also known as intermuscular and intramuscular fat) is positively related to meat quality including tenderness, flavor, and juiciness. Thus, understanding the cell origin and regulation mechanism of skeletal muscle fat infiltration is important for developing therapies against human myopathies as well as for improving meat quality. Notably, age, sarcopenia, oxidative stress, injury, and regeneration can activate adipogenic differentiation potential in myoblasts and affect fat accumulation in skeletal muscle. In addition, several transcriptional and nutritional factors can directly induce transdifferentiation of myoblasts into adipocytes. In this review, we focused on the recent progress in understanding the muscle‐to‐adipocyte differentiation and summarized and discussed the genetic, nutritional, and physiological factors that can induce transdifferentiation of myoblasts into adipocytes. Moreover, the regulatory roles and mechanisms of these factors during the transdifferentiation process were also discussed.

中文翻译：

诱导成肌细胞转分化为脂肪细胞的因素

在几种肌病中观察到骨骼肌中的脂肪浸润，这与肌肉功能障碍有关，并且与胰岛素抵抗、糖尿病、肥胖和衰老密切相关。在动物生产中，骨骼肌脂肪（也称为肌间脂肪和肌内脂肪）与肉质（包括嫩度、风味和多汁）呈正相关。因此，了解骨骼肌脂肪浸润的细胞起源和调节机制对于开发针对人类肌病的疗法以及改善肉质非常重要。值得注意的是，年龄、肌肉减少症、氧化应激、损伤和再生可以激活成肌细胞的成脂分化潜能并影响骨骼肌中的脂肪积累。此外，几种转录和营养因子可以直接诱导成肌细胞转分化为脂肪细胞。在这篇综述中，我们重点介绍了肌肉向脂肪细胞分化的最新进展，并总结和讨论了可诱导成肌细胞转分化为脂肪细胞的遗传、营养和生理因素。此外，还讨论了这些因素在转分化过程中的调节作用和机制。

更新日期：2020-09-28

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