Efficient Synthesis of ω‐[18F]Fluoroaliphatic Carboxylic Esters and Acids for Positron Emission Tomography,European Journal of Organic Chemistry

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Efficient Synthesis of ω‐[18F]Fluoroaliphatic Carboxylic Esters and Acids for Positron Emission Tomography
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-09-29 , DOI: 10.1002/ejoc.202000934
Mariia S. Larkina _{1,

2} , Anastasia V. Ozerskaya _{1,

3} , Ekaterina V. Podrezova ₁ , Mikhail V. Belousov _{1,

2} , Vladimir Tolmachev _{1,

4} , Viktor V. Zhdankin _{1,

5} , Mekhman S. Yusubov ₁

Affiliation

The important PET tracers, ω‐[¹⁸F]fluoroaliphatic carboxylic acid derivatives, were prepared by nucleophilic radiofluorination of the readily available iodocarboxylic esters. Methyl 6‐[¹⁸F]fluorohexanoate was further applied as a starting material for the preparation of the succinimide ester (NHS ester)‐containing bifunctional radiofluorinated prosthetic group in two simple steps, 10 min each.

中文翻译：

用于正电子发射断层成像的ω-[18F]氟代脂族羧酸和酸的高效合成

重要的PET示踪剂是ω-[ ¹⁸ F]氟代脂族羧酸衍生物，是通过对易得的碘代羧酸酯进行亲核放射性氟化制备的。通过两个简单的步骤（每次10分钟），将6- [ ¹⁸ F]氟己酸甲酯进一步用作制备含琥珀酰亚胺酯（NHS酯）的双功能放射性氟化假体的原料。

更新日期：2020-10-29

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