当前位置: X-MOL 学术Green Synth. Catal. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biosynthesis of organic molecules via artificial cascade reactions based on cytochrome P450 monooxygenases
Green Synthesis and Catalysis ( IF 8.2 ) Pub Date : 2020-07-27 , DOI: 10.1016/j.gresc.2020.05.002
Ren-Jie Li , Zhongwei Zhang , Carlos G. Acevedo-Rocha , Jing Zhao , Aitao Li

Cytochrome P450 monooxygenases (P450s) play crucial roles in the oxyfunctionalization of non-activated hydrocarbons, thus bridging the gap between simple molecules and high value-added fine chemicals. The introduction of P450s into artificially designed cascade reactions provides an exciting opportunity to accomplish challenging reactions and access organic compounds that cannot be achieved by traditional chemical catalysts or by natural metabolic pathways. The main objective of this review is to provide an overview of different types of artificially designed multi-step cascades in which P450s are involved as key catalysts in the biosynthesis of various organic molecules. The different efforts include in vitro multi-enzymatic biocatalytic cascades, in vivo biocatalytic cascades as well as chemo-enzymatic hybrid cascades. Overall, this work provides an overview of cascade reactions involving P450s with various potential applications for the industrial production of food, cosmetics, polymers and pharmaceuticals.



中文翻译:

通过基于细胞色素P450单加氧酶的人工级联反应生物合成有机分子

细胞色素P450单加氧酶(P450)在非活化烃的氧官能化中起关键作用,从而弥合了简单分子与高附加值精细化学品之间的鸿沟。将P450引入人工设计的级联反应中提供了令人兴奋的机会,可以完成具有挑战性的反应并获得传统化学催化剂或天然代谢途径无法实现的有机化合物。这篇综述的主要目的是概述不同类型的人工设计的多步级联反应,其中P450作为各种有机分子生物合成中的关键催化剂。不同的努力包括在体外的多酶生物催化级联,在体内生物催化级联以及化学酶促杂交级联。总的来说,这项工作概述了涉及P450的级联反应,其在食品,化妆品,聚合物和药物的工业生产中具有各种潜在的应用。

更新日期:2020-09-29
down
wechat
bug