During last two decades, transition-metal catalyzed asymmetric reactions under continuous flow system have attracted a widespread attention. With its prominent advantages including higher safety and efficiency, precise control, better heat/mass transfer, easier scale-up and better sustainability, it has impressed both the academia and related industries. However, comparing with the prosperous development of transition-metal catalyzed asymmetric reactions in batch, utilization of this type of chemistry under continuous flow is still at an early stage. To inspire more potential industrial application and further studies of this chemistry in flow, this review sum?marized the recent advances of transition-metal catalyzed asymmetric reactions under continuous flow. Moreover,we further discussed the encountered challenges including reactor engineering, catalyst design, catalyst deactivation, pressure drop, clogging, side reactions etc., as well as their corresponding solutions and achievements in this mini-review.

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2015年至2020年初连续流动下过渡金属催化的不对称反应

在最近的二十年中，连续流系统下过渡金属催化的不对称反应引起了广泛的关注。它具有显着的优势，包括更高的安全性和效率，精确的控制，更好的热/质量传递，更容易的扩展规模和更好的可持续性，给学术界和相关行业留下了深刻的印象。但是，与过渡金属催化的不对称反应的繁荣发展相比，在连续流动下使用这种化学物质仍处于早期阶段。为了激发更多的潜在工业应用和对该流态化学的进一步研究，本综述总结了连续流下过渡金属催化不对称反应的最新进展。此外，我们进一步讨论了遇到的挑战，包括反应堆工程，