Cell entry and egress are essential steps in the viral life cycle that govern pathogenesis and spread. Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses implicated in human disease that serve as tractable models for studies of pathogen–host interactions. In this review we discuss the function of intracellular vesicular transport systems in reovirus entry, trafficking, and egress and comment on shared themes for diverse viruses. Designing strategic therapeutic interventions that impede these steps in viral replication requires a detailed understanding of mechanisms by which viruses coopt vesicular trafficking. We illuminate such targets, which may foster development of antiviral agents.

细胞进入和流出是控制发病机制和传播的病毒生命周期中的重要步骤。哺乳动物正呼肠孤病毒（呼肠孤病毒）是与人类疾病有关的无包膜病毒，可作为研究病原体-宿主相互作用的易处理模型。在这篇综述中，我们讨论了细胞内囊泡运输系统在呼肠孤病毒进入、运输和流出过程中的功能，并评论了多种病毒的共同主题。设计阻碍病毒复制这些步骤的战略性治疗干预措施需要详细了解病毒参与囊泡运输的机制。我们阐明了这些目标，这可能会促进抗病毒药物的发展。