Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Considerable effort is currently made by scientists to understand the molecular mechanisms underlying its development, but no clear answer has been attained yet. One reason might be that the needed multidisciplinarity of this type of research is pushed to extreme conditions. Among the mechanisms identified, protein-lipid interaction could play an important role. Understanding these interactions is crucial, and multiple approaches have been developed which have led to increased knowledge in this area.

This review, focusing over the last 10 years, presents how techniques spanning from analytical chemistry to physical chemistry help assessing protein-lipid interaction in AD. It focuses on proving its existence, identifying the sites of interaction, and understanding the consequences such interaction would have regarding further evolution of the protein and the lipid. Finally, it shows that understanding protein-lipid interaction in AD effectively requires multi-technique-based strategies.

阿尔茨海默氏病（AD）是老年人痴呆症的最常见原因。目前，科学家们为了解其发展的分子机制付出了巨大的努力，但尚未获得明确的答案。一个原因可能是这种研究需要的多学科性被推到了极端的条件。在确定的机制中，蛋白质-脂质相互作用可能起重要作用。了解这些相互作用至关重要，并且已经开发了多种方法，这些方法导致了对该领域的更多了解。

这篇综述着眼于过去的十年，介绍了从分析化学到物理化学的技术如何帮助评估AD中的蛋白-脂质相互作用。它着重于证明其存在，鉴定相互作用的位点，并了解这种相互作用对蛋白质和脂质进一步进化的后果。最后，它表明有效理解AD中的蛋白质-脂质相互作用需要基于多种技术的策略。