Caseous lymphadenitis (CLA) caused by Corynebacterium pseudotuberculosis is characterized by the development of abscesses, mainly in superficial and internal lymph nodes, visceral and reproductive organs in small ruminants. This study aims to examine the histopathological changes in reproductive organs of goats immunized with killed vaccine of C. pseudotuberculosis. In this study, twenty four (24) clinically healthy bucks and does were divided into four groups A, B, C and D. Animals in groups A and B were immunized with 0.5 and 1% formalin killed vaccine, respectively; followed by a booster dose. After the booster dose of immunization, groups A, B and C were challenged with C. pseudotuberculosis at 10⁶ cfu/ml. Goats in group D were immunize and unchallenged and left as control group. All C. pseudotuberculosis infected animals were euthanized humanely 12 weeks post-challenged. Tissue samples such as testes, epididymis, spermatic cord, penis, pituitary gland, mammary gland, vulva, vagina, cervix, uterus, fallopian tube and ovaries were collected for histopathology study. Microscopic examination of all tissues (testes, seminiferous tubules, spermatic cord, penile tissues and the pituitary gland) in the male reproductive organs of the bucks that were inoculated with 2 ml of 0.5% and 1.0% of C. pseudotuberculosis killed vaccine showed normal (animals inoculated with 1.0%) to mild (animals inoculated with 0.5%) histopathological changes when compared with those from group C which showed varying degrees of histopathological changes (p < 0.01) in their various tissues. For the female does, similar histopathological changes were observed for the various tissues examined (ovaries, fallopian tubes, uterine horns, uterine tissues, cervix, vaginal, vulva, mammary glands and the pituitary glands) in which the vaccinated groups A &B showed a significantly (p < 0.001) less histopathological changes when compared with those in group C that showed varying degrees of histopathological changes in the reproductive organs investigated. This study showed the efficacy of C. pseudotuberculosis killed vaccine protecting against reproductive tissue damages cause by the active infection with the live bacteria in both bucks and does in the study area.

假结核杆菌引起的干酪性淋巴结炎（CLA）的特点是脓肿的发展，主要在小反刍动物的浅表和内部淋巴结，内脏和生殖器官中。这项研究的目的是研究用假结核杆菌灭活疫苗免疫的山羊生殖器官的组织病理学变化。在这项研究中，将二十四（24）个临床健康的雄鹿和雄鹿分为A，B，C和D四组。A和B组的动物分别用0.5％和1％的福尔马林杀死的疫苗免疫；其次是加强剂量。加强剂量的免疫后，在10 ^6点用假结核梭菌攻击A，B和C组。 cfu /毫升。将D组中的山羊进行免疫和无挑战性处理，并作为对照组。在受到攻击后12周，将所有感染假结核杆菌的动物人道安乐死。收集诸如睾丸，附睾，精索，阴茎，垂体，乳腺，外阴，阴道，子宫颈，子宫，输卵管和卵巢的组织样品用于组织病理学研究。显微镜检查雄鹿雄性生殖器官中接种2 ml 0.5％和1.0％假结核杆菌的所有组织（睾丸，生精管，精索，阴茎组织和垂体）与C组不同组织中不同程度的组织病理学变化（p <0.01）相比，灭活疫苗显示正常（动物接种1.0％）至轻度（动物接种0.5％）的组织病理学变化。对于女性，在所检查的各种组织（卵巢，输卵管，子宫角，子宫组织，子宫颈，阴道，外阴，乳腺和垂体）观察到相似的组织病理学变化，其中接种A和B组的情况明显。 （p <0.001）与C组相比，在所研究的生殖器官中显示不同程度的组织病理学变化的组织病理学变化较少。这项研究显示了假结核念珠菌的功效 在研究区域内，无论是雄性还是雄性，活疫苗对活菌的主动感染都可以防止杀伤性疫苗免受生殖组织损害。