Nanotechnology has allowed rapid advancements in nanomachines for variety of biomedical applications, including drug delivery, due to their loading and transporting capabilities. Utilizing pnictogen, such as arsenic, antimony and bismuth, as nanomachines for biomedical applications are still in infancy. Herein, template-less arsenene-based Janus nanomachines with layered structure which allowed high loading capacity are explored by specifically modifying arsenene nanoparticles with platinum, forming As-Pt nanomotors. Their motion capabilities, biocompatibility and drug loading competency were thoroughly investigated. The results showed fast, biocompatible, high drug loading and high cellular uptake of As-Pt nanomotors. These findings open new direction in arsenene nanoparticles as nontoxic self-propelled drug carrier applications.

纳米技术由于其装载和运输能力，已使纳米机器在各种生物医学应用（包括药物输送）中得到了快速发展。利用光生原，例如砷，锑和铋，作为用于生物医学应用的纳米机器仍处于起步阶段。在本文中，通过用铂专门修饰砷纳米颗粒，形成As-Pt纳米马达，探索了具有分层结构的无模板的基于砷的Janus纳米机械，该纳米结构允许高负载能力。他们的运动能力，生物相容性和载药能力进行了彻底的调查。结果表明，As-Pt纳米马达具有快速，生物相容性，高载药量和高细胞摄取率的特点。这些发现为砷纳米颗粒作为无毒自推药物载体的应用开辟了新的方向。