Candida spp. are opportunistic fungi that can cause severe infections especially in immunocompromised patients. Candidiasis is currently the most frequent fungal disease affecting humans globally. This rise is attributed to the vast increase in resistance to antifungal agents. In recent years, the epidemiological and clinical relevance of fungal infections caused by Candida species have attracted a lot of interest with increasing reports of intrinsic and acquired resistance among Candida species. Thus, the formulation of novel, and efficient therapy for Candida infection persists as a critical challenge in modern medicine. The use of nanoparticle as a potential biomaterial to achieve this feat has gained global attention. Nanoparticles have shown promising antifungal activity, and thus, could be seen as the next generation antifungal agents. This review concisely discussed Candida infection with emphasis on anti-candida resistance mechanisms and the use of nanoparticles as potential therapeutic agents against Candida species. Moreover, the mechanisms of activity of nanoparticles against Candida species, recent findings on the anti-candida potentials of nanoparticles and future perspectives are also presented.

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使用纳米颗粒作为治疗念珠菌感染的替代治疗剂：最新概述和未来展望

念珠菌属 是机会性真菌，可引起严重感染，尤其是在免疫功能低下的患者中。念珠菌病是目前影响全球人类最常见的真菌疾病。这种上升归因于抗真菌剂耐药性的大幅增加。近年来，念珠菌属物种引起的真菌感染的流行病学和临床相关性引起了很多兴趣，越来越多的念珠菌属物种之间存在内在和获得性耐药性的报道。因此，为念珠菌感染制定新的、有效的治疗方法仍然是现代医学中的一个关键挑战。使用纳米粒子作为潜在的生物材料来实现这一壮举已经引起了全球的关注。纳米颗粒已显示出有希望的抗真菌活性，因此可被视为下一代抗真菌剂。这篇综述简明地讨论了念珠菌感染，重点是抗念珠菌耐药机制和纳米颗粒作为针对念珠菌种类的潜在治疗剂的用途。此外，还介绍了纳米颗粒对念珠菌物种的活性机制、纳米颗粒抗念珠菌潜力的最新发现和未来前景。