Purpose of Review

The purpose of this paper is to review and synthesize current literature in which neurochemical and structural brain imaging were used to investigate chronic migraine (CM) pathophysiology and to further discuss the clinical implications.

Recent Findings

Spectroscopic and structural MRI studies have shown the presence of both impaired metabolism and structural alterations in the brain of CM patients. Metabolic changes in key brain regions support the notion of altered energetics and homeostasis as part of CM pathophysiology. Furthermore, CM, like other chronic pain disorders, may undergo structural reorganization in pain-related brain regions following near persistent endogenous painful input. Finally, both imaging techniques may provide potential biomarkers of disease state and progression and may help guide novel therapeutic interventions or strategies.

Summary

Spectroscopic and structural MRI have revealed novel aspects of CM pathophysiology. Findings from the former support the metabolic theory of migraine pathogenesis.

中文翻译：

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慢性偏头痛的脑代谢和结构

审查目的

本文的目的是回顾和综合目前使用神经化学和结构脑成像研究慢性偏头痛 (CM) 病理生理学的文献，并进一步讨论其临床意义。

最近的发现

光谱和结构 MRI 研究表明，CM 患者大脑中存在代谢受损和结构改变。关键大脑区域的代谢变化支持将能量和体内平衡改变作为 CM 病理生理学的一部分的概念。此外，与其他慢性疼痛疾病一样，CM 可能会在接近持续的内源性疼痛输入后在与疼痛相关的大脑区域中进行结构重组。最后，这两种成像技术都可以提供疾病状态和进展的潜在生物标志物，并可能有助于指导新的治疗干预或策略。

概括

光谱和结构 MRI 揭示了 CM 病理生理学的新方面。前者的研究结果支持偏头痛发病机制的代谢理论。