Erysipelothrix rhusiopathiae VR-2 is a commercially available live attenuated vaccine strain widely used in Russia, Kazakhstan, and a number of European countries for immunization of pigs against swine erysipelas. The draft genome sequence of E. rhusiopathiae strain VR-2 reported in this paper is 1,704,727 bp in length, has CG content of 36.5%, and contains 1680 genes, including 51 tRNA, 3 rRNA, and 1408 protein-coding genes. Comparative sequence analysis between Fujisawa (serovar 1a), VR-2 and six other serovar N strains of E. rhusiopathiae revealed wide genetic variability of the chromosomal region essential for serovar-specific antigenicity and virulence of E. rhusiopathiae strains. We have performed a BLAST search and found 12 genomic loci potentially specific for the E. rhusiopathiae VR-2 strain. These data could be helpful for developing genetic assays for differentiation of field isolates and this live attenuated vaccine strain, which is especially important for epizootical monitoring of swine erysipelas in countries, where the live vaccine strain E. rhusiopathiae VR-2 is used for pig immunization, as well as for the design of recombinant vaccines against swine erysipelas. The genome of E. rhusiopathiae VR-2 has been submitted in GenBank under accession number RJTK00000000.1.

Erysipelothrix rhusiopathiae VR-2 是一种市售的减毒活疫苗株，广泛用于俄罗斯、哈萨克斯坦和一些欧洲国家，用于对猪进行猪丹毒免疫。的基因组序列草图E.丝菌菌株VR-2本文报道的长度为1704727个碱基，具有36.5％CG含量，并含有1680个基因，其中有51个的tRNA，rRNA的3和1408蛋白质编码基因。藤泽（血清变型1a）中，VR-2和六个其他血清型之间比较序列分析Ñ的菌株E.丝菌揭示了染色体区域所必需的宽遗传变异对的特定血清型抗原性和毒力E.丝菌菌株。我们进行了 BLAST 搜索，发现了 12 个可能对E. rhusiopathiae VR-2 菌株具有特异性的基因组位点。这些数据可能有助于开发用于区分田间分离物和这种减毒活疫苗株的基因检测方法，这对于在使用猪丹毒活疫苗株E. rhusiopathiae VR-2 进行猪免疫的国家中猪丹毒的流行监测尤为重要，以及针对猪丹毒的重组疫苗的设计。E. rhusiopathiae VR-2的基因组已提交到 GenBank，登录号为 RJTK00000000.1。