Probing the glycopolymer–ion interaction via specific ion effects,Polymer Chemistry

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Probing the glycopolymer–ion interaction via specific ion effects
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-09-28 , DOI: 10.1039/d0py01221a
Xiancheng Meng _{1,

2,

3,

4,

5} , Die Li _{1,

2,

3,

4,

5} , Aotian Zhang _{1,

2,

3,

4,

5} , Qiang Zhang _{1,

2,

3,

4,

5}

Affiliation

Ions are known to play vital roles in the specific recognition between glycopolymers and lectins; however, it is challenging to characterize such interactions. Herein, specific ion effects are used to probe the interactions between glycopolymers and ions. The effects of different anions and cations on the cloud points of thermoresponsive glycopolymers were investigated. Specific ion effects were found to be pronounced even under low salt concentrations for nonlinear poly(ethylene glycol) (PEG) analogues. The anion's order of the salting-in to salting-out effect for nonlinear PEG analogues was in coincidence with the traditional Hofmeister series. However, due to the presence of high-polarity hydroxyl groups from saccharides, unexpected salting-in effects were observed for the glycopolymers under relatively low concentrations of anions. Both salting-in and salting-out effects could be observed when the glycopolymer was solubilized in aqueous solutions containing low- or high-concentration heavy metal salts. The direct binding of ions to the saccharide units could significantly change the polymers’ hydrophilicity and cloud points, which highlighted the importance of hydroxyl groups in the ionic effects of polymers. The specific ion effect of thermoresponsive glycopolymers could act as a facile tool to study the interactions between saccharides and ions.

中文翻译：

通过特定离子效应探测糖聚合物与离子的相互作用

众所周知，离子在糖聚合物和凝集素之间的特异性识别中起着至关重要的作用。然而，表征这种相互作用具有挑战性。在本文中，特定的离子效应用于探测糖聚合物与离子之间的相互作用。研究了不同阴离子和阳离子对热响应性糖聚合物浊点的影响。发现即使在低盐浓度下，对于非线性聚（乙二醇）（PEG）类似物，特定的离子效应也很明显。非线性PEG类似物从阴离子到盐析作用的阴离子顺序与传统的Hofmeister系列吻合。但是，由于糖中存在高极性羟基，因此在相对较低的阴离子浓度下，对于糖聚合物观察到了意外的盐析作用。当将糖聚合物溶解在含有低或高浓度重金属盐的水溶液中时，既可以观察到盐溶作用，也可以观察到盐析作用。离子与糖单元的直接结合可以显着改变聚合物的亲水性和浊点，这突出了羟基在聚合物离子效应中的重要性。热响应性糖聚合物的特定离子效应可作为研究糖类与离子之间相互作用的简便工具。这突出了羟基在聚合物离子效应中的重要性。热响应性糖聚合物的特定离子效应可作为研究糖类与离子之间相互作用的简便工具。这突出了羟基在聚合物离子效应中的重要性。热响应性糖聚合物的特定离子效应可作为研究糖类与离子之间相互作用的简便工具。

更新日期：2020-10-06

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