Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy,New Journal of Chemistry

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Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020-09-28 , DOI: 10.1039/d0nj04395h
Abhilash Sharma _{1,

2,

3,

4,

5} , Pranjal Gogoi _{1,

2,

3,

4,

5}

Affiliation

A versatile transition-metal free synthetic strategy has been developed for the direct synthesis of 6-substituted indoloquinazolinones from 2-acyl-4-quinazolinones and aryne precursors under mild conditions. This cascade strategy proceeds via successive C–N and C–C bond formation in a single reaction vessel by simple treatment with CsF and K₂CO₃. A diverse range of 6-substituted indoloquinazolinones were synthesized in good yields with excellent functional group tolerance.

中文翻译：

由芳烃和2-酰基-4-喹唑啉酮合成6-取代的吲哚喹唑啉酮：无过渡金属的CN和CC键形成策略

已经开发了一种通用的无过渡金属的合成策略，用于在温和条件下由2-酰基-4-喹唑啉酮和芳烃前体直接合成6-取代的吲哚喹唑啉酮。这种级联策略是通过在单个反应容器中用CsF和K ₂ CO ₃进行简单处理而连续形成C–N和C–C键来进行的。以良好的产率和优异的官能团耐受性合成了多种6-取代的吲哚并喹唑啉酮。

更新日期：2020-10-13

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