To this day, the coronavirus disease 2019 (COVID-19) pandemic has not shown signs of abating. Moreover, the virus responsible for the pandemic, severe acute respiratory syndrome coronavirus 2, has evolved into three different variants. This phenomenon highlights an even greater need to develop drugs and vaccines to control the rate of infection and spread of the disease. As of July 7, 2020, at least 160 vaccine candidates, 21 of which have entered the clinical trial phase, have been developed. This article describes the latest advances in development, reliable platforms, strategies used, and challenges that remain in developing COVID-19 vaccines.

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2019 年冠状病毒病疫苗开发：概述


迄今为止，2019 年冠状病毒病 (COVID-19) 疫情尚未显示出减弱的迹象。此外，导致此次大流行的病毒——严重急性呼吸综合征冠状病毒2——已经进化成三种不同的变种。这种现象凸显出更需要开发药物和疫苗来控制疾病的感染率和传播。截至2020年7月7日，至少已开发出160种候选疫苗，其中21种已进入临床试验阶段。本文介绍了 COVID-19 疫苗开发的最新进展、可靠的平台、使用的策略以及开发中仍然存在的挑战。