The prognostic value of microvessel density (MVD) in head and neck squamous cell carcinoma (HNSCC) remains disputable. The purpose of this study was to comprehensively determine the prognostic value of MVD in HNSCC. Relevant literatures were identified using PubMed, Embase, and Cochrane Library. A meta-analysis was performed to clarify the prognostic role of MVD in HNSCC patients and different subgroups. A total of 14 eligible articles were included in this meta-analysis. The combined hazard ratio (HR) and 95% confidence interval (95% CI) for overall survival (OS) of 11 studies was 1.663 (1.236-2.237, ), and the pooled HR and 95% CI for progression-free survival (PFS) of 7 studies was 2.069 (1.281-3.343, ). Subgroup analyses were also performed on different issues, such as regional distribution of patients, age, tumor location, antibody, and treatment strategy. To conclude, high MVD is associated with worse OS and PFS in patients with HNSCC.

中文翻译：

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头颈部鳞状细胞癌中微血管密度的预后价值：荟萃分析。

微血管密度（MVD）在头颈部鳞状细胞癌（HNSCC）中的预后价值仍然存在争议。这项研究的目的是全面确定MVD在HNSCC中的预后价值。使用PubMed，Embase和Cochrane Library鉴定了相关文献。进行荟萃分析以阐明MVD在HNSCC患者和不同亚组中的预后作用。本荟萃分析共纳入14篇合格文章。11项研究的总生存率（OS）的总危险比（HR）和95％置信区间（95％CI）为1.663（1.236-2.237，）， 7项研究的无进展生存期（PFS）的合并HR和95％CI为2.069（1.281-3.343，）。还对不同问题进行了亚组分析，例如患者的区域分布，年龄，肿瘤位置，抗体和治疗策略。总之，高MVD与HNSCC患者的OS和PFS恶化有关。