Reversible addition fragmentation chain transfer (RAFT) aqueous emulsion polymerization of vinyl acetate (VAc) is performed using poly[di(ethylene glycol) vinyl ether] (PDEGV) macromolecular chain transfer agents (macro-CTAs) including RAFT end-unfunctionalized PDEGV (up to 32%). Emulsion polymerization directly induces PDEGV-b-PVAc diblock copolymer assemblies in water. This facile formulation enables the production of various particle morphologies, such as spheres, rods (ellipsoids), and vesicles, depending on the composition of the block copolymer. Many other examples of RAFT emulsion polymerization syntheses only result in the formation of kinetically trapped spheres, even when targeting highly asymmetric diblock compositions. However, despite being stabilized only by homopolymer PDEGV macro-CTAs, including PDEGV, PVAc-based nanoparticles with various morphologies can be obtained as PDEGV-b-PVAc assemblies. RAFT aqueous emulsion polymerization owes its success to recent RAFT polymerizations of hydroxy-functionalized vinyl ethers. We investigated the RAFT polymerization of DEGV, analyzed the kinetics of PDEGV-b-PVAc nanoparticle formation, and observed the morphology of resultant particles in detail. We also developed a phase diagram for this RAFT aqueous emulsion polymerization formulation that reliably predicts the precise block compositions associated with well-defined particle morphologies. RAFT aqueous emulsion polymerization of vinyl acetate (VAc) was performed using poly[di(ethylene glycol) vinyl ether] (PDEGV) macromolecular chain transfer agents. The emulsion polymerization directly induced PDEGV-b-PVAc diblock copolymer assemblies in water. Owing to the characteristic PDEGV as a highly hydrophilic steric stabilizer, this facile formulation enables the production of various particle morphologies, such as spheres, rods (ellipsoids), and vesicles, depending on the composition of the block copolymer. Each morphology change in the nanoparticles via RAFT aqueous emulsion polymerization owes its success to the recent RAFT polymerizations of vinyl ethers.

中文翻译：

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聚[二(乙二醇)乙烯基醚]稳定的聚(醋酸乙烯酯)纳米粒子通过醋酸乙烯酯的RAFT水乳液聚合具有各种形态

醋酸乙烯酯 (VAc) 的可逆加成断裂链转移 (RAFT) 水乳液聚合使用聚 [二(乙二醇) 乙烯基醚] (PDEGV) 大分子链转移剂 (macro-CTA) 进行，包括 RAFT 末端未官能化的 PDEGV (up到 32%）。乳液聚合直接诱导水中的 PDEGV-b-PVAc 双嵌段共聚物组装。根据嵌段共聚物的组成，这种简便的配方能够生产各种颗粒形态，例如球体、棒状（椭圆体）和囊泡。RAFT 乳液聚合合成的许多其他示例仅导致形成动力学捕获的球体，即使在针对高度不对称的二嵌段组合物时也是如此。然而，尽管仅通过均聚物 PDEGV 宏观 CTA 稳定，包括 PDEGV，具有各种形态的基于 PVAc 的纳米粒子可以作为 PDEGV-b-PVAc 组件获得。RAFT 水乳液聚合的成功归功于最近羟基官能化乙烯基醚的 RAFT 聚合。我们研究了 DEGV 的 RAFT 聚合，分析了 PDEGV-b-PVAc 纳米颗粒形成的动力学，并详细观察了所得颗粒的形态。我们还为这种 RAFT 水性乳液聚合配方开发了一个相图，可以可靠地预测与明确定义的颗粒形态相关的精确嵌段组成。使用聚[二(乙二醇)乙烯基醚](PDEGV)大分子链转移剂进行醋酸乙烯酯(VAc)的RAFT水乳液聚合。乳液聚合直接诱导水中的 PDEGV-b-PVAc 双嵌段共聚物组装。由于 PDEGV 作为高度亲水性空间稳定剂的特性，这种简便的配方能够根据嵌段共聚物的组成生产各种颗粒形态，例如球体、棒状（椭圆体）和囊泡。通过 RAFT 水乳液聚合在纳米粒子中的每个形态变化都归功于最近的乙烯基醚 RAFT 聚合。